MOTS-c

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial MT-RNR1 locus, making it a member of the mitochondrial-derived peptide (MDP) class. This catalog item is supplied as a high-purity synthetic analog (sequence MRWQEMGYIFYPRKLR) for in vitro and biochemical investigation. It is provided strictly for laboratory research use only and is not intended for human or veterinary use.

In published literature, MOTS-c has been studied as a regulator of cellular energy sensing, with reported associations to AMP-activated protein kinase (AMPK) activation, glucose flux, and the folate-methionine metabolic axis. It has also been examined for nuclear translocation under metabolic stress and interaction with casein kinase 2. Researchers use the peptide as a tool compound in cell-based assays and mitochondrial biology models.

Store lyophilized powder at -20 C protected from light and moisture; stable for extended periods. Reconstituted solutions should be stored at -20 C or below in aliquots to avoid repeated freeze-thaw cycles.

For laboratory research use only. Reconstitute in sterile water or bacteriostatic water; the peptide is soluble in aqueous buffer. Not for human or veterinary use.