NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a dinucleotide coenzyme composed of an adenine nucleotide and a nicotinamide nucleotide joined through their phosphate groups. As an obligate electron acceptor, it cycles between its oxidized (NAD+) and reduced (NADH) states, serving as a central carrier in glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation. Supplied as the free acid (CAS 53-84-9) for laboratory research use only.

In research settings, NAD+ is widely employed as a substrate and cofactor for enzymatic assays involving dehydrogenases, sirtuins, poly(ADP-ribose) polymerases, and cyclic ADP-ribose synthases. It is studied in models of cellular metabolism, redox homeostasis, mitochondrial function, DNA-repair signaling, and pathways associated with cellular senescence and longevity biology.

Store desiccated at -20C protected from light and moisture; the compound is hygroscopic and sensitive to heat and aqueous degradation. Aliquot to minimize freeze-thaw cycles. Stable for extended periods when stored as supplied.

For laboratory research use only. Not for human or veterinary use. Reconstitute in deionized water or buffered aqueous solution; prepare working solutions fresh and keep on ice, as NAD+ degrades in alkaline and elevated-temperature conditions.