Tirzepatide

Tirzepatide (LY3298176) is a synthetic 39-amino-acid linear peptide engineered as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. Its backbone is derived from the native GIP scaffold and incorporates two aminoisobutyric acid (Aib) residues at positions 2 and 13, a C-terminal amide, and a C20 fatty diacid moiety conjugated through a linker at the Lys20 side chain, which supports albumin association and extended molecular stability.

This material is supplied as a research reagent for in vitro and laboratory investigation. It is widely used as a reference agonist in studies of incretin receptor pharmacology, receptor binding and activation assays, cyclic AMP signaling, and comparative structure-activity work. Reported research applications include cell-based receptor characterization and metabolic signaling pathway models. For laboratory research use only; not for human or veterinary use.

Store lyophilized powder at -20C; protect from light and moisture. Reconstituted solutions should be aliquoted and stored at -20C to -80C and used promptly. Avoid repeated freeze-thaw cycles.

For laboratory research use only. Typically reconstituted in sterile bacteriostatic or ultrapure water; for assay use, dilute further in the appropriate buffer system. Centrifuge vial before opening.