Retatrutide

Retatrutide (LY3437943) is a synthetic single-chain peptide engineered as a unimolecular triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors. Built on a 39-amino-acid backbone, it incorporates non-coded residues including 2-aminoisobutyric acid (Aib) and 2-methylleucine to confer protease resistance, a C-terminal serinamide, and a C20 diacid fatty-acid moiety linked through a gamma-glutamate/AEEA spacer that promotes albumin association and extended in vitro stability.

This compound is supplied strictly for laboratory research use only and is not intended for diagnostic or any in vivo human application. It is widely used as a reference ligand for interrogating incretin and glucagon receptor pharmacology, characterizing G-protein-coupled receptor signaling bias, and supporting structure-activity and binding studies in cell-based and biochemical assay systems. Reported receptor potencies (EC50 values in the sub-nanomolar to low-nanomolar range across the three targets) make it a useful tool for comparative metabolic signaling investigations.

Store lyophilized powder at -20C protected from light and moisture; for long-term storage, -80C is recommended. Once reconstituted, store at 2-8C and use within a limited working period; avoid repeated freeze-thaw cycles.

For laboratory research use only. Reconstitute in sterile water or bacteriostatic-free aqueous buffer; aliquot prior to freezing to minimize freeze-thaw degradation. Not for human or veterinary use.