Semaglutide

Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist analog featuring a 31-amino-acid backbone derived from human GLP-1(7-37). It incorporates an alpha-aminoisobutyric acid (Aib) substitution at position 8 conferring resistance to DPP-4 cleavage, an Arg34 substitution, and a C18 fatty diacid acylated at Lys26 through a gamma-glutamate/OEG hydrophilic linker that promotes albumin binding. These structural elements make it a frequently referenced model compound for incretin-pathway studies.

This research-grade material is supplied for laboratory use only and is not intended for human or veterinary use. It is studied in in vitro receptor-binding and signal-transduction assays, structure-activity investigations of acylated peptides, and cell-based models exploring GLP-1 receptor pharmacology and downstream metabolic signaling cascades. Each lot is characterized by HPLC and mass spectrometry to confirm identity and purity.

Store lyophilized powder at -20C protected from light and moisture; stable for up to 24 months. After reconstitution, store at 2-8C and use within several weeks, or aliquot and store at -20C to -80C to minimize freeze-thaw cycles.

Reconstitute in sterile bacteriostatic or distilled water; the peptide is soluble in aqueous buffers. Avoid repeated freeze-thaw cycles by preparing single-use aliquots. For laboratory research use only.