Semaglutide — Certificate of Analysis

Lot SM10-2026-001 of GLP-1 SM assayed at 99.51% peptide purity by RP-HPLC against a ≥95.0% release specification, 4.51 percentage points clear of it. Released 08/01/2026 by ILS Laboratories, ISO/IEC 17025 Accredited. Acylated 31-residue GLP-1 analog with Aib8 substitution and C18 diacid lysine modification for metabolic signaling research.

Net peptide content measured 10.37 mg against a 10 mg label — the mass of actual peptide in the vial, as distinct from salts, water and counter-ions. It is reported rather than graded, so it carries no pass/fail.

Full QC panel

Analyte	Specification	Result	Status
Peptide Purity (HPLC)	≥ 95.0%	99.51%	Pass
Identity (HPLC-RTM)	Semaglutide Confirmed	Confirmed	Pass
Net Peptide Content	Report Only	10.37 mg	—
Fentanyl Screen	Immunoassay, 50 ng/mL cutoff	Not Detected	Pass

Sterility & endotoxin

Test	Specification	Result	Status
Sterility (PCR)	No Growth	No Growth	Pass
Endotoxin (USP <85>)	Report Result	NMT 0.05 EU/mL	Reported

Endotoxin is reported as a measured value rather than graded pass/fail: acceptable limits depend on route and matrix, and no universal threshold applies to research-use material. The laboratory reports the figure and leaves the judgement to you.

Elemental impurities

Panel	Method	Result	Status
Arsenic, cadmium, chromium, lead, mercury	ICP-MS, USP <233>	5 of 5 under limit	Pass

Per-element measurements are on the signed certificate below and in the laboratory's own record.

Reference data

Property	Value
Compound	Semaglutide
Also known as	NN9535, GLP-1 analog (Aib8, Arg34)
Sequence	HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG (X = Aib at position 8 of GLP-1 numbering; Lys26 acylated with C18 diacid via gamma-Glu/OEG linker)
Molecular formula	C187H291N45O59
Molecular weight	4113.58 g/mol
CAS number	910463-68-2
Physical form	Lyophilized powder
Storage	Store lyophilized powder at -20C protected from light and moisture; stable for up to 24 months. After reconstitution, store at 2-8C and use within several weeks, or aliquot and store at -20C to -80C to minimize freeze-thaw cycles.